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May 21 2025
2In a significant stride toward inclusive Alzheimer's research, the Davos Alzheimer’s Collaborative (DAC) has partnered with The American University in Cairo (AUC) and University College London (UCL) to launch the North African Dementia Registry (NADR). This initiative marks the first dementia-focused registry in North Africa, aiming to develop a comprehensive multiomics dataset that reflects the region's genetic diversity.
Recognizing the underrepresentation of non-European populations in dementia studies, this collaboration seeks to fill critical knowledge gaps. "This collaboration will bolster our understanding of Alzheimer’s disease in a region characterized by remarkable genetic diversity," stated Vaibhav Narayan, Executive Vice President at DAC. "Over time, these insights will inform locally relevant prevention and intervention strategies for communities often overlooked in global research efforts."
The project involves collecting blood samples and conducting cognitive assessments from over 1,500 individuals aged 55 and older across ten Egyptian governorates. Participants include those at high risk for cognitive decline and individuals with existing memory issues. The study also examines environmental factors such as air pollution and pesticide exposure, which may influence the development and progression of Alzheimer's disease.
To enhance the depth of genetic analysis, DAC has selected Pacific Biosciences (PacBio) as the technology partner for the project. PacBio's long-read sequencing technology allows for more accurate detection of genetic variations and epigenetic changes associated with Alzheimer's disease. "Our long-read sequencing technology is uniquely suited to deliver the high-quality genomic data needed to explore the complex genetic landscape of Alzheimer’s disease," said Neil Ward, Vice President and General Manager of EMEA at PacBio.
Dr. Mie Rizig, UCL NADR lead and clinical senior research fellow in the Department of Neuromuscular Diseases at UCL Queen Square Institute of Neurology, emphasized the importance of diverse datasets in dementia research. "Addressing the global challenge of dementia requires diverse, high-quality datasets. With PacBio’s technology and workflows, we can accelerate our understanding of the genetic architecture of populations in North Africa and uncover novel biomarkers and potential therapeutic targets."
The data generated from this collaboration will be made accessible to researchers worldwide through the Alzheimer’s Disease Data Initiative (ADDI) platform, promoting further innovation in Alzheimer's disease research. Mohamed Salama, AUC-NADR lead and professor at AUC’s Institute of Global Health and Human Ecology, highlighted Egypt's strategic position. "With a population exceeding 110 million, Egypt serves as a unique bridge between Africa and the Middle East, offering a rich tapestry of genetic and cultural heritage. This collaboration not only promises to benefit the Egyptian population but also aims to advance our collective understanding of dementia in the region and beyond."
This initiative represents a significant step toward addressing the global challenge of dementia by incorporating diverse populations into research efforts, ultimately aiming to develop more effective diagnostic tools and therapeutic solutions for Alzheimer's disease worldwide.
Source:https://www.the-scientist.com/first-of-its-kind-egyptian-multiomics-dataset-aims-to-advance-dementia-research-73019
This is non-financial/medical advice and made using AI so could be wrong.
